Molecular Docking Study of GABA receptor protein with two ligands, Cannabinol and Tetrahydrocannabinol

Gamma-Aminobutyric acid (GABA)


Gamma-Aminobutyric acid (GABA) receptor protein in one of key proteins in the neuronal signaling pathways and communications. The given sequence, corresponding to chain A of GABA receptor, is proceeded into docking process against two ligands, Cannabinol and Tetrahydrocannabinol. Protein-ligand docking results indicate that both ligands show inhibitory properties against the GABA receptor, highlighting their roles as GABA-inhibitor drug candidates. Furthermore, Tetrahydrocannabinol shows higher inhibition which could be advantageous in more inhibition requirements.

This project is carried on at Bioinformatics Camp (BioinfCamp), with the help of projects team, and under the supervision of Mr. Roohparvar.

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